SportsLine's advanced model has locked in its Week 11 NFL betting picks and football predictions from 10,000 simulations

Before looking at SportsbookWire staff’s Week 11 NFL picks, here are the against-the-spread (ATS) and Over/Under (O/U) leaders, according to Teamrankings.com. The Detroit Lions (8-1 straight up) and Pittsburgh Steelers (7-2) share the best ATS records in the NFL at 7-2 apiece. The Washington Commanders (7-3) are 7-2-1 ATS.

I have utter faith in Nick Sirianni’s ability to botch this, but Philly’s pass defense is even better than Pittsburgh’s — and the Steelers stifled Jayden Daniels late to earn a comeback win in Week 10.