While the loss already had to sting by itself, San Francisco's three-time All-Pro left tackle Trent Williams may find himself having even more disdain for the Week 6 loss. With 5:52 remaining in the fourth quarter and the 49ers trailing 27-19, Williams got tangled up with Tampa Bay safety Tykee Smith.

The San Francisco 49ers activated star tight end George Kittle from injured reserve on Saturday after he had missed the past five games with a hamstring injury. Kittle went down in the first half of the season opener for San Francisco but returned to practice this week and is ready to return to game action on Sunday night against the Atlanta Falcons.

Wide receiver Kendrick Bourne returned to the San Francisco 49ers after a few years in New England, and his coaches are impressed by his work.

The San Francisco 49ers need to add to the linebacker position ahead of the trade deadline after Fred Warner's season-ending injury. One analyst has proposed a trade with the New Orleans Saints that won't cost much in draft capital.

With Kittle reinstated from IR on Saturday, Willis is no longer needed on the 49ers' active roster, though the latter could remain in San Francisco and sign with the team's practice squad.

San Francisco 49ers tight end George Kittle was activated from injured reserve Saturday after missing five games due to a hamstring injury.

The San Francisco 49ers have shockingly released a wide receiver amid the team's multiple injuries on offense.

We had the opportunity to sit down with San Francisco 49ers legend Frank Gore on Friday, thanks to his sponsorship with Lowe’s. Frank teams up with Lowe’s to help support the Earn Your Sundays Trailer, where they do giveaways, have Madden Games, and test your football skills.