Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen receptor alpha (mERα) signaling in specific cell types of female mice affects ...

Bone homeostasis relies on a dynamic balance between bone-forming osteoblasts and bone-resorbing osteoclasts. Epigenetic mechanisms—heritable modifications that regulate gene expression without ...

Treating breast cancer remains a major medical challenge worldwide. This is largely due to the ability of breast cancer cells ...

For patients suffering from traumatic injuries that leave behind "volumetric" gaps—where significant bone and blood vessels ...

Tooth loss and bone degeneration are problems that modern medicine still struggles to fix. Data from the National Bone Health Policy Institute shows that 10 million Americans over the age of 50 have ...

Bone is a dynamic organ that continually adapts its mass and microarchitecture in response to mechanical forces. This adaptive process, known as mechanotransduction, converts physical stimuli into ...

Bone implants often fail to fully integrate with surrounding tissue, limiting their effectiveness in regeneration. A natural but often overlooked cellular process could hold the key to better outcomes ...

In a recent study, Associate Professor Makoto Ikeya (Department of Clinical Application) and his team of researchers successfully established a method to generate jawbone-like organoids (mini-organs) ...

Two distinct stem cell lineages that drive tooth root and alveolar bone formation have been identified by researchers from Science Tokyo. Using genetically modified mice and lineage-tracing techniques ...

In a basic science study last year, researchers discovered that taurine, available in energy drinks and as a supplement, feeds the growth of leukemia stem cells. A new study recently published by the ...

Genetic inactivation of γ-carboxylation in osteoblasts increased trabecular bone mass and reduced osteoclast activity in male mice, revealing a vitamin K-dependent GAS6 signaling pathway that ...

Finding an effective treatment for osteosarcoma, the most common type of bone cancer in children and young adults, has puzzled medical researchers for 40 years. Now, a new study by researchers at Case ...