Case in point, on the Chargers’ first offensive drive of Sunday’s game against the Indianapolis Colts, Austin Deculus went down with a serious-looking injury at left tackle. Foster Sarell replaced him on Herbert’s blind side.

Los Angeles Chargers head coach Jim Harbaugh provided a positive injury update for star edge rusher Khalil Mack on Wednesday, but a negative one on left tackle Joe Alt.

The Chargers play the Colts this Sunday, and they will be without left tackle Joe Alt. Alt is listed as doubtful with a high ankle sprain that he suffered in Week 4 against the Giants. He participated in practice on Thursday for the first time since the injury.

Los Angeles Chargers wideout Quentin Johnston enjoyed a massive breakout to start the season and took fantasy football managers with him before suffering an injury. Before suffering an injury that caused him to miss a game, Johnston caught 26 passes for 377 yards and four scores, numbers that still have him leading the team in receiving.

Ahead of Sunday's matchup between the Colts and the Chargers, let's take a closer look at the final injury reports and the potential impact.

Justin Herbert and the Los Angeles Chargers have been without star left tackle Joe Alt since an injury in Week 4.

This article was originally published on www.si.com/nfl/chargers as Chargers latest injury news hints RB room takes yet another hit. The Los Angeles Chargers simply cannot seem to escape the injury bug at the running back position as they head into a Week 7 showdown with the Indianapolis Colts that features the AFC’s top seed up for grabs.

The Indianapolis Colts will be without cornerback Charvarius Ward for Sunday's Week 7 game against the LA Chargers. Ward suffered a concussion in pre-game warmups before the Arizona Cardinals game when he collided with tight end Andrew Ogletree.