Downstream bioprocessing steps have long been a challenge to drug manufacturers, particularly the chromatography step for purification of monoclonal antibodies (mAbs). The complexity of traditional ...

Controlling chromatography systems for downstream processing of biotherapeutics is challenging because of the highly nonlinear behavior of feed components and complex interactions with binding phases.

Bed-height Optimization Can Reduce Cost and Increase Speed of Production Affinity chromatography is potentially the most selective method for protein purification and is often included as a primary ...