Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication is initiated in eukaryotes. Using Vanderbilt's state ...
Researchers led by University of Tsukuba have discovered rdxPolA, a putative DNA polymerase involved in replicating ancestral mitochondrial genomes, in diverse eukaryotic lineages. Based on the ...
DNA polymerases in eukaryotic cells constitute a family of specialised enzymes responsible for the accurate duplication and repair of the genome. Replicative polymerases α, δ and ε form the core ...
Eukaryotic DNA replication is initiated at multiple origins through a tightly regulated sequence of events: origin licensing, helicase activation and assembly of the replisome. The replicative ...
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A protein thought to play a supporting role in DNA replication actually facilitates the whole process
Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...
DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...
On their own, however, polymerases aren't good at staying on the DNA strand. They require CTF18-RFC in humans and Ctf18-RFC in yeast to thread a ring-shaped clamp onto the DNA leading strand, and ...
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