Scientists have revealed the DNA sequence code of the “initiator,” a crucial sequence that kick-starts gene activation. A ...

Nearly every cell in the human body contains essentially the same genetic information, yet different cells activate different ...

Nearly every cell in the human body contains essentially the same genetic information, yet different cells activate different ...

Every human's genome has millions of genetic variants, but most have little to no effect, making it difficult for clinicians to make medical diagnoses based on genetic differences. Using patterns of ...

Every time a cell divides, it must accurately copy its entire genetic instruction manual. Before this process can begin, cells load their DNA-copying motor—a complex of six subunits known as the ...

Researchers have gained a clearer insight into how common alterations to the structure of DNA affect the process of DNA replication. These structural changes can put a stop to replication, causing ...

When a wound does not heal properly, it leaves a scar. Similarly, mutations—which are permanent changes to genetic code—are ...

Scheme showing the structure of cytosine, 5-methylcytosine, and 5-hydroxymethylcytosine. Adding a methyl group to the DNA base cytosine represses gene expression in mammalian cells. To remove the ...

From the Bedalov Lab, Translational Science and Therapeutics and Human Biology Divisions When I asked Foss and Bedalov whether the known replication origins in yeast shared any sequence-level features ...