Itovebi, Ibrance, and Faslodex significantly improved OS in PIK3CA-mutated, HR-positive, HER2-negative advanced breast cancer compared to placebo. The INAVO120 trial showed a median OS of 34.0 months ...
In HR+/HER- early breast cancer, the DFS benefits of adjuvant ribociclib plus NSAI treatment compared to NSAI alone persisted even a year after treatment completion.
The evERA study showed significant PFS improvements with giredestrant plus everolimus in ER-positive, HER2-negative breast ...
In September 2025, the U.S. Food and Drug Administration (FDA) approved several new cancer therapies and supportive care ...
The FDA has approved the combination of lurbinectedin (Zepzelca) and atezolizumab (Tecentriq) as a first-line maintenance treatment for patients with extensive-stage small cell lung cancer (ES-SCLC) ...
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More Evidence for Lower Ribociclib Dose in Advanced Breast Cancer
Patients receiving ribociclib 400 mg had a shorter QTcF (12.5 vs 19.7 ms at cycle 1 day 15, 2 hours post-dose) and a lower ...
HERTHENA-Breast04 Phase 3 Trial of Patritumab Deruxtecan Initiated in Patients with Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer Previously Treated with Endocrine Therapy The ...
The approval is based on findings from a phase 3 study which demonstrated the drug’s superiority over chemotherapy. The FDA has approved trastuzumab deruxtecan (Enhertu) for the treatment of adults ...
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