While sanguinarine has gained recognition for antimicrobial and antineoplastic activities, its complex conjugated structure and low abundance in plants impede broad applications. Here, we demonstrate ...

Intein is a naturally found protein splicing element that undergoes self-excision from a protein precursor with concomitant joining (splicing) of the flanking protein sequences called exteins. This ...

Why do problems occur with a special variant of 'protein glues', the split inteins, that severely limit their use in producing proteins? A team has now answered this question. Proteins are the ...

Controlling protein function in mammalian cells could get a little easier. Researchers at Harvard University describe a way to turn on proteins with self-splicing protein domains called inteins.

Controlling protein function in mammalian cells could get a little easier. Researchers at Harvard University describe a way to turn on proteins with laboratory-evolved self-splicing protein domains ...

The SCN1A gene is too large to fit into aconventional viral delivery systems. Scientists overcame this hurdle with a pioneering "split-intein" mechanism, which is like two separate trucks, delivering ...

Proteins are the building blocks of life. They consist of folded peptide chains, which in turn are made up of a series of amino acids. From stabilising cell structure to catalysing chemical reactions, ...