Adenylosuccinate lyase (ADSL) deficiency is an inherited metabolic disorder that impairs purine metabolism. ADSL is a key enzyme in both the de novo synthesis and the purine nucleotide cycle, ...

Northwestern Medicine scientists have uncovered a surprising link between a tiny cellular engine and the way cancer cells build the DNA they need to proliferate, according to a new study published in ...

This is a preview. Log in through your library . Abstract Rates of purine synthesis de novo, as measured by the incorporation of [14C]formate into newly synthesized purines, have been determined in ...

Northwestern Medicine scientists have uncovered a surprising link between a tiny cellular engine and the way cancer cells build the DNA they need to proliferate, according to a new study published in ...

While most enzymatic activity is conducted through chemical binding interactions between molecules, in some cases, the mere presence of an enzyme can affect intracellular functions. While exploring ...