This image illustrates the process of gene transcription within a cell. The DNA double helix unwinds to expose a specific sequence, allowing RNA polymerase to synthesize a complementary pre-mRNA ...

The molecular machinery that normally builds proteins inside cells has now taken on a new role as a "switch." A research team ...

A team led by researchers at UT Southwestern Medical Center has developed deep learning models to identify a simple set of rules that govern the activity of promoters—regions of DNA that initiate the ...

A new Northwestern Medicine study published in the Proceedings of the National Academy of Sciences has explored the impacts ...

Transcription-coupled DNA damage repair represents a specialised branch of nucleotide excision repair that ensures rapid removal of lesions from the transcribed strand of active genes. When RNA ...

In the study of bacteria, a longstanding dogma has held that two molecular machines—RNA polymerase, which leads the way in ...

The epigenetic modifier MLL4 has an unassuming name—the 4, for instance, indicates it's just one in a family of such ...

While scientists have studied the molecular steps involved in gene expression for decades, many questions still remain about this fundamental process. To transcribe genes, RNA polymerase II (RNA Pol ...

Scientists at the Massachusetts Institute of Technology (MIT) have invented a new single-cell nascent RNA sequencing technique that lets them observe the timing of gene and enhancer activation in ...

Thomas Gingeras did not intend to upend basic ideas about how the human body works. In 2012 the geneticist, now at Cold Spring Harbor Laboratory in New York State, was one of a few hundred colleagues ...