The San Francisco 49ers have a big decision looming ahead of the Nov. 4 NFL trade deadline after key injuries.

The San Francisco 49ers were dealt another significant injury blow after Sunday's victory over the Atlanta Falcons.

The San Francisco 49ers' injury-riddled defense under Robert Saleh will be tested by the Atlanta Falcons. Can the Niners' ...

Huff will miss a game or two, while quarterback Brock Purdy is "a reach" to return from his toe injury in Week 8.

The injuries are especially starting to pile up on the defensive side of the ball. San Francisco is already without Nick Bosa ...

The San Francisco 49ers need edge rusher help and that has led one analyst to predict the team will make a big trade for Miami Dolphins edge rusher Bradley Chubb.

Christian McCaffrey led the San Francisco 49ers to a 20-10 victory over Atlanta with 201 yards from scrimmage and two ...

Bryce Huff and center Jake Brendel will both be sidelined "a couple of weeks" with hamstring injuries, coach Kyle Shanahan ...

You would think that the 49ers losing their second-best pass rusher, Bryce Huff, would entice them to make a trade, but it ...

Their ability to maintain a winning record without multiple key impact players on both sides of the ball has shown they have ...

The San Francisco 49ers continue to lose quality players to injury, as cornerback Renardo Green went down against the Atlanta ...

San Francisco 49ers HC Kyle Shanahan gave a major update on the health of Niners ED Bryce Huff after he sustained an injury ...