There is an increasing demand for comprehensive genome analyses of single cells. In cancer genetics, single-cell approaches allow monitoring minimal residual disease or the assessment of heterogeneity ...
Three chromosome-21-specific YACs (760H5, 757E11, and 750H2) isolated from the CEPH YAC library [11] were used to generate probes, by Alu-PCR. PCR amplification of YAC recombinant DNA was carried out ...
Expert Rev Mol Diagn. 2013;13(3):251-255. aCGH is not necessarily fully informative with regards to the number of copies gained in the patient; for example, a threefold gain of 18p detected in aCGH ...
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