The Bills remain alone atop the Super Bowl 60 odds despite a loss to the Patriots on Sunday Night Football in Week 5. They are followed by the Lions and Eagles.

Despite losing back-to-back regular season games in Weeks 5 and 6, the Buffalo Bills are still the favorites at most online betting sites to win the Super Bowl this season. With a record of 4-2 after six weeks of play,

The Indianapolis Colts are proving they're legitimate Super Bowl contenders at 6-1 with an elite offense and transformed defense under Shane Steichen.

We're six weeks into the 2025 NFL season and the Super Bowl contenders are starting to separate from the pretenders. One team that had a huge win this past weekend emerged as the biggest winner with computer models now projecting a possible Lombardi Trophy for them.

A gutsy Thursday night overtime win for the San Francisco 49ers (+1700) and backup QB Mac Jones pushed the Niners to the top of the second tier from +2500. Although they lost as nearly a touchdown favorite at home to the Niners, the Los Angeles Rams (+1700) barely moved from +1600 the previous week.