The entire show revolved around the main event, the "final meeting" between John Cena and Randy Orton, in the latter's hometown of St. Louis, Missouri. There were a few highlights, but the match went off the rails late,

WWE Backlash 2025 was the site of the last time iconic rivals John Cena and Randy Orton collided inside the squared circle. The main event showdown took place in Orton’s hometown of St. Louis, Missouri,