Case in point, on the Chargers’ first offensive drive of Sunday’s game against the Indianapolis Colts, Austin Deculus went down with a serious-looking injury at left tackle. Foster Sarell replaced him on Herbert’s blind side.

The Los Angeles Chargers announced on Saturday that they have activated edge rusher Khalil Mack and linebacker Denzel Perryman from the injured reserve. Mack had been sidelined for the past four games with an elbow injury, while Perryman missed five games due to an ankle injury.

Los Angeles Chargers linebacker Khalil Mack will return to action for Sunday's home game against the Indianapolis Colts. CBS Sports' Matt Zenitz reported that Mack would be activated off of injured reserve and play on Sunday before the Chargers confirmed the news. Mack was elevated along with fellow linebacker Denzel Perryman.

This article was originally published on www.si.com/nfl/chargers as Chargers latest injury news hints RB room takes yet another hit. The Los Angeles Chargers simply cannot seem to escape the injury bug at the running back position as they head into a Week 7 showdown with the Indianapolis Colts that features the AFC’s top seed up for grabs.

The Chargers are also without All-Pro offensive tackle Rashawn Slater for the year after he suffered a torn patellar tendon in training camp. Star edge rusher Khalil Mack (dislocated elbow) remains on the IR, and offensive tackle Joe Alt (ankle) missed week 5 against Washington.

The Chargers could be getting some much needed help soon, as Khalil Mack's practice window has been activated.

Justin Herbert and the Los Angeles Chargers have been without star left tackle Joe Alt since an injury in Week 4.

The veteran edge rusher is seeking a second opinion regarding his MCL injury, but he's currently expected to be sidelined over the next couple of weeks. Ebukam has played 208 defensive snaps over the Colts ' first seven games this season,