A novel study uncovers how a subtle chemical tweak transforms the naturally occurring phytotoxin into a powerful molecular glue, 12-deoxyfusicoccin (12-dFC), that locks 14-3-3 proteins onto the ...

Skin squamous cell carcinoma (SCC) arises from dysregulated epidermal homeostasis characterized by aberrant keratinocyte proliferation and pathological angiogenesis. The eukaryotic translation ...

During development, many crucial genes help organisms form properly. One of those genes is myogenic determination gene number 1 (MyoD), which can exert a powerful influence as a “genome organizer." It ...

A high throughput screen of >30,000 diverse repressor domains from across the tree of life identifies repressor domains with unique structures that underpin enhanced epigenetic effector domain potency ...

Atrial fibrillation (AF) is a highly prevalent condition that can cause or exacerbate heart failure, is an important risk factor for stroke, and is associated with pronounced morbidity and death.

As sessile organisms, plants have to continually adapt their growth and architecture to the ever-changing environment. To do so, plants have evolved distinct molecular mechanisms to sense and respond ...

The neuron-restrictive silencer factor (NRSF), also known as repressor element 1 (RE-1) silencing transcription factor (REST) or X2 box repressor (XBR), is a zinc finger transcription factor that is ...

Abstract: Genetic oscillators play an important role in cell physiology. In this paper, we investigate the global kinetics of an activator-repressor genetic oscillator through the bifurcation analysis ...

Colonies of bacteria containing the repressilator circuit develop different patterns of “growth rings” over time depending on what stage the repressilator circuit was in when each colony’s seed ...