Chronic inflammation and depression are deeply connected. Research shows that people with depression often have elevated inflammatory markers — especially C-reactive protein (CRP), interleukin-6 (IL-6) and TNF-α. These cytokines can alter neurotransmitter pathways, disrupt serotonin metabolism, and even reduce neuroplasticity — all contributing to low mood, fatigue, and brain fog. In simple terms: When the body is inflamed, the brain feels it. Key scientific findings: 📌 A large meta-analysis fo