Can levothyroxine cause weight gain? The answer may surprise you and it is a definite yes. By the way, this information all applies to SYNTHROID as well. So whether you are taking Synthroid or levothyroxine, both medications can lead to weight gain. How can a medication which is designed to improve thyroid function ultimately lead to weight gain? The answer has to do with how this medication is metabolized and utilized in your body. Levothyroxine and Synthroid contain the hormone known as T4 or
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