‎Dr. Jude Abourdan جود أبوردن‎ on Instagram: "The medication I started was Ocrevus-zunovo It is a subcutaneous (under-the-skin) formulation of ocrelizumab, a humanized monoclonal antibody used to treat multiple sclerosis (MS) - Targets CD20-positive B lymphocytes - Leads to B-cell depletion → reduces inflammation, demyelination, and disease progression in MS. . Within days–weeks, circulating B cells drop significantly, that increases infection risk, reduced immunoglobulin levels with long-term u

Answers (if you’re doing the UKMLA this year there’s a little something at the end of the caption for you) Pathophysiology of myeloma Malignant clonal proliferation of plasma cells in the bone marrow Production of monoclonal immunoglobulin (paraprotein/M-protein) and/or free light chains, causing immune paresis and increased infection risk End-organ damage via multiple mechanisms: Bone destruction: Plasma cells secrete cytokines (IL-6, MIP-1α) → increased osteoclast activity and decreased osteob