Epilepsy (Generalized Tonic–Clonic Seizures) – Drug of Choice Tab. Sodium Valproate 500 mg PO BD Dose: Start 10–15 mg/kg/day, increase to 20–30 mg/kg/day in divided doses. Uses First-line drug for generalized tonic–clonic seizures. Also useful in myoclonic and absence seizures. Mechanism of Action ↑ GABA levels → enhances inhibitory transmission. Blocks voltage-gated sodium channels → stabilizes neuronal membranes. Blocks T-type calcium channels → suppresses abnormal discharges. Prescription Tab
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Aazer Nawab on Instagram: "Valproate-related hyperammonemic encephalopathy (VHE) is a serious but reversible complication of valproic acid therapy. A condition where serum ammonia rises due to valproate, leading to altered mental status, even when LFTs are normal and valproate levels may be therapeutic. -Mechanism Valproate: •Inhibits carbamoyl phosphate synthetase-1 (CPS-1) → blocks urea cycle •Causes carnitine deficiency •Produces toxic metabolites such as 4-en-VPA •Leads to accumulation of am
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